Lactiplantibacillus plantarum 22A-3 isolated from pickle suppresses ovalbumin-induced food allergy in BALB/c mice and 2,4-dinitrochlorobenzene-induced atopic dermatitis in NC/Nga mice

In the previous study, pickle-derived Lactiplantibacillus plantarum 22A-3 (LP22A3) suppressed ear edema in passive cutaneous anaphylaxis by its oral administration. Moreover, LP22A3 treatment directly to RBL-2H3 cells shows no effect on β-hexosaminidase release from but inhibited using Caco-2/RBL-2H3 co-culture system stimulated with apical side. this administration of decreased total IgE and ovalbumin (OVA) specific contents blood BALB/c mice induced food allergy OVA. development dermatitis 2,4-dinitrochlorobenzene (DNCB) which was used develop atopic dermatitis-like lesions NC/Nga mice. This alleviation further correlated a reduction elevated serum IgE, transepidermal water loss acanthosis LP22A3-treated group compared vehicle-treated positive group. composed Caco-2 cells, side before or after sensitization anti-dinitrophenyl (DNP) antibody indicated different β−hexosaminidase RBL-2H3. Its release, not sensitization, indicating that affected mast sensitized allergen through intestinal epithelial cells. These results suggest may have potential therapeutic property for Type 1 hypersensitivity dermatitis.